Clinical studies have provided substantial evidence supporting the effectiveness of topical vitamin C in skincare. Here are some key findings from research:

Antioxidant Protection:

• A study published in the Journal of Investigative Dermatology found that topical application of vitamin C reduced UV-induced erythema (redness) by 52% and sunburn cell formation by 40-60%.

• Another study published in the Journal of Cosmetic Dermatology demonstrated that vitamin C provided significant protection against UV-induced DNA damage and oxidative stress in human skin.

Collagen Synthesis:

• Research published in the Journal of Clinical and Aesthetic Dermatology showed that topical vitamin C significantly increased collagen production in human skin, leading to improvements in skin firmness and elasticity.

• A study published in the Journal of Drugs in Dermatology found that topical vitamin C increased collagen synthesis in photoaged skin, resulting in visible reductions in fine lines and wrinkles.

Reduction of Hyperpigmentation:

• A clinical trial published in the Journal of the American Academy of Dermatology showed that a topical formulation containing 10% vitamin C significantly improved the appearance of hyperpigmentation, leading to a more even skin tone.

• Another study published in Dermatologic Surgery found that a combination of vitamin C and glycolic acid was effective in reducing hyperpigmentation and improving skin texture.

Enhancement of Sun Protection:

• A study published in the Journal of Investigative Dermatology demonstrated that topical vitamin C enhanced the photoprotective effects of sunscreen, reducing UV-induced erythema and DNA damage in human skin.

• Research published in the Journal of the American Academy of Dermatology showed that topical vitamin C reduced sunburn cell formation and DNA damage in UV-irradiated skin.

Wound Healing:

• A study published in the Journal of Cutaneous and Aesthetic Surgery found that topical vitamin C accelerated wound healing by promoting collagen synthesis and angiogenesis (the formation of new blood vessels).

• Clinical research published in the Indian Journal of Dermatology demonstrated that vitamin C applied topically to surgical wounds reduced inflammation, improved epithelialization, and enhanced overall wound healing.

Anti-inflammatory Properties:

• A study published in the Journal of Clinical and Aesthetic Dermatology showed that topical vitamin C reduced inflammation in acne-prone skin and improved the overall appearance of acne lesions.

• Research published in the Journal of Drugs in Dermatology found that vitamin C reduced erythema and inflammation in response to various irritants in human skin.

The following are medical grade skincare products formulated with Vitamin-C and are best sellers:

Dermavenue C & E Essential Serum with Ferulic Acid

Obagi Professional-C Serum 20%

Revision Skincare C+ Correcting Complex 30% 

iS Clinical Pro-Heal Serum Advance+

Overall, clinical studies consistently demonstrate the efficacy of topical vitamin C in improving various aspects of skin health, including antioxidant protection, collagen synthesis, reduction of hyperpigmentation, enhancement of sun protection, wound healing, and anti-inflammatory effects. These findings support the dermatologist recommendation for incorporating topical vitamin C into skincare routines to achieve healthier, more youthful-looking skin.

Topical vitamin C is often recommended by dermatologists for skincare due to its numerous scientifically proven benefits and its ability to address various skin concerns.